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203

抑制剂 & 化合物

62

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Cat. No.	Product Name	Target	Signaling Pathways
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T8507	MAC-545496	Antibacterial	Microbiology/Virology
	MAC-545496 是一种抗毒剂，可逆转耐甲氧西林的菌株中的 β-内酰胺耐药性。它是糖肽抗性相关蛋白 R 的纳摩尔抑制剂，对全长 GraR 蛋白具有很强的结合亲和力。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T19794	Temafloxacin 替马沙星,Omniflox	Antibiotic	Microbiology/Virology
	Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂，对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。
T1031	Cloxacillin sodium monohydrate Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) 有抗菌作用，对Staphylococcus aureus25923 的最小抑菌浓度为256 mg/L。
T7804	Garenoxacin mesylate hydrate Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)	Antibacterial	Microbiology/Virology
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮，具有强抗菌活性，抗呼吸道病原体。
T1389	Dyclonine hydrochloride 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl	Sodium Channel; Antibacterial; Antifungal	Membrane transporter/Ion channel; Microbiology/Virology
	Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分，具有显著的杀菌和杀真菌作用。
T1283	Clinafloxacin 克林沙星,PD 127391,CI-960,AM-1091	Antibacterial; Antibiotic	Microbiology/Virology
	Clinafloxacin (CI-960) 是一种高效广谱氟喹诺酮类抗生素，抑制革兰氏阳性、革兰氏阴性和厌氧病原体。它对金黄色葡萄球菌的 DNA 促旋酶和拓扑异构酶 IV 有抑制作用，IC50值分别为 0.92 µg/ml 和 1.62 µg/ml。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T7179	Garenoxacin BMS284756,加雷沙星	Antibacterial	Microbiology/Virology
	Garenoxacin (BMS284756) 是一种新型的口服 des-fluoro(6) 喹诺酮，有抗菌活性，可抑制呼吸道病原体。
T1293	Gatifloxacin BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中，它有抗细菌性结膜炎作用。
T64316	VP-4604 1-((4-Nitrophenyl)sulfonyl)piperidine
	VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌（MRSA）化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用，MIC 为4-8μg/mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长，其生长抑制率达到95%以上。
T12126	MUT056399 Fab-001	Antibacterial	Microbiology/Virology
	MUT056399 (Fab-001) 是一种金黄色葡萄球菌和大肠杆菌的 FabI 酶的高效抑制剂，IC50值分别为 12 nM 和 58 nM。
TQ0063	Zoliflodacin ETX0914,AZD0914	DNA gyrase; DNA/RNA Synthesis; Topoisomerase; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Zoliflodacin (ETX0914) 是一种新型螺旋嘧啶三酮，对革兰氏阳性和阴性生物有抗菌活性，对金黄色葡萄球菌的b>MIC90值为0.25 μg/mL。他也是细菌DNA 促旋酶/拓扑异构酶的抑制剂。
T22387	NSC 55655 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione	Others	Others
	NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。
T20936	Lauramine oxide LDAO,Dimethylaurylamine oxide,十二烷基二甲基氧化胺,Refan,Lauryldimethylamine oxide	Antibacterial	Microbiology/Virology
	Lauramine oxide (Refan) 对大肠杆菌和金黄色葡萄球菌等常见细菌有效，但它是非变性的，可用于溶解蛋白质。
T4208	Targocil	Antibacterial	Microbiology/Virology
	Targocil 是一种磷壁酸生物合成的抑菌抑制剂，可抑制甲氧西林敏感金黄色葡萄球菌 (MSSA) 和耐甲氧西林金黄色葡萄球菌 (MRSA) 的生长，对于 MRSA 和 MSSA 的MIC90值都为 2 μg/mL。
TP1663L	CysHHC10 acetate CysHHC10 acetate(1408311-03-4 free base)	Antibacterial	Microbiology/Virology
	CysHHC10 acetate 对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性，对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌的 MIC 分别为 10.1、20.2、2.5 和 1.3 mM。
T61159	Antibacterial agent 26	Antibacterial	Microbiology/Virology
	Antibacterial agent 26 是一种抗菌化合物，是有效的DHFR 抑制剂（金黄色葡萄球菌DHFR Ki 为0.020 nM）。
TQ0113	Iclaprim 艾拉普林,AR-100	Antibacterial; Antibiotic	Microbiology/Virology
	Iclaprim (AR-100) 是一种细菌二氢叶酸的选择性新型抑制剂, 可抑制金黄色葡萄球菌的生长, 其 MIC90值为 0.06 μg/mL。
T6638	Retapamulin 瑞他莫林,SB-275833	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Retapamulin (SB-275833) 是一种能结合金黄色葡萄球菌和大肠杆菌核糖体的局部抗生素，Kd 为3 nM。
T28229	Olanexidine hydrochloride OPB2045,OPB-2045,OPB-2045 HCl,OPB 2045	Antibacterial	Microbiology/Virology
	Olanexidine hydrochloride (OPB-2045 HCl) 对革兰氏阳性菌和革兰氏阴性菌具有杀菌活性。 Olanexidine hydrochloride 破坏金黄色葡萄球菌的膜完整性。
T10586L	BPH-1358 NSC50460	Others; Antibacterial	Microbiology/Virology; Others
	BPH-1358 (NSC-50460) 是一种人 FPPS 和 UPPS 抑制剂，IC50值分别为 1.8 μM 和 110 nM，对金黄色葡萄球菌的 MIC 值大约为 250 ng/mL。
TN6672	Cyclo(L-Phe-L-Pro)	Free radical scavengers; COX; Antibacterial; Antifungal	Immunology/Inflammation; Microbiology/Virology; Neuroscience; oxidation-reduction
	Cyclo(L-Phe-L-Pro) 具有广谱抗菌和抗真菌活性。 Cyclo(L-Phe-L-Pro) 对耐甲氧西林金黄色葡萄球菌和棉子肠球菌具有活性。
TP1412	RNAIII-inhibiting peptide TFA RNAIII-inhibiting peptide(TFA),L-酪氨酰-L-丝氨酰-L-脯氨酰-L-色氨酰-L-苏氨酰-L-天冬氨酰胺酰-L-苯丙氨酸	Antibacterial	Microbiology/Virology
	RNAIII-inhibiting peptide TFA (RNAIII-inhibiting peptide(TFA))(228544-21-6 free base) 抑制肽（TFA）抑制金黄色葡萄球菌，对蜂窝织炎、角膜炎、化脓性关节炎、骨髓炎和乳腺炎等疾病有效。
T19642	Nilofabicin CG 0549,CG-0549,CG-400549,CG 400549,CG0549,CG400549	Antibacterial	Microbiology/Virology
	Nilofabicin (CG-400549) 是一种有效的烯酰-(酰基-载体-蛋白)还原酶下降(FabI)抑制剂，可用于治疗复杂急性疾病的研究。
TP1773L	PGLa acetate	Antibacterial; Antibiotic	Microbiology/Virology
	PGLa acetate 是 magainin 抗生素肽家族的 21 个残基成员。
T21358	Dalbavancin BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星	Antibacterial; Antibiotic	Microbiology/Virology
	Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T72330	Antibacterial agent 19
	Antibacterial agent 19 是一种有效的抗菌剂。Antibacterial agent 19 对K. pneumoniae，(M-R)S. aureus 和 (M-R,V-R)S. aureus 具有抗菌活性, 其 MIC 值为 0.022, 0.022 和 0.045 mg/mL。
T76658	SYNV-cyclo(CGGYF)
	SYNV-cyclo(CGGYF)，一种源自人葡萄球菌(S. hominis)C5的自诱导肽，能抑制金黄色葡萄球菌(S. aureus)的活性，展现出研究金黄色葡萄球菌引发的上皮损伤及炎症的潜力。
T36594	4-Chloroguaiacol
	4-Chloroguaiaco (4-Chloro-2-methoxyphenol) is a phenol derivative, with antimicrobial activity. 4-Chloroguaiaco shows inhibition against S. aureus and E. coli with MICs of both 110 μg/mL[1]. [1]. Patrícia Fontes Pinheiro, et al. Semisynthetic Phenol Derivatives Obtained from Natural Phenols: Antimicrobial Activity and Molecular Properties. J Agric Food Chem. 2018 Jan 10;66(1):323-330.
T10587	BPH-652	Others	Others
	BPH-652 is an S. aureus dehydrosqualene synthase (CrtM) inhibitor (Ki: 1.5 nM; IC50: 100-300 nM for S. aureus pigment formation).
T80293	RP-1
	RP-1为一抗菌肽，具备针对S. aureus、S. typhimurium、E. coli及C. albicans的抗菌活性。
T27389	Frequentin
	Frequentin, an antibiotic originally isolated from P. frequentans, is active against bacteria (MICs = 200 and 300 µg/ml for B. subtilis and S. aureus, respectively) and fungi.
T76658L	SYNV-cyclo(CGGYF) TFA
	SYNV-cyclo(CGGYF) TFA 是人葡萄球菌 (S. hominis)C5 自诱导肽，能够抑制金黄色葡萄球菌 (S. aureus) 的活性，并具备探索金黄色葡萄球菌 (S. aureus) 引发的上皮损伤和炎症潜力。
T64069	Antibacterial agent 87
	Antibacterial agent 87 是一种有效的抗细菌剂，能够作用于 MRSA (MIC: 0.125 μg/ml)、MRSE (MIC: 0.0625 μg/ml) 和 S. aureus (MIC: 0.0625 μg/ml)。
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T80373	Maximin 77
	Maximin 77为抗菌肽，针对S. aureus表现出抗菌活性（MIC: 18.8 μg/mL），且对人红细胞具有溶血性。
T38102	Decatromicin B
	Decatromicin B is a bacterial metabolite that has been found in Actinomadura. It is active against Gram-positive bacteria, including several strains of S. aureus (MICs = 0.39-0.78 μg/ml), two strains of methicillin-resistant S. aureus (MRSA; MICs = 0.39 and 0.78 μg/ml), as well as M. luteus, B. subtilis, and C. bovis (MICs = 0.78, 0.78, and 6.25 μg/ml, respectively).
T61911	Antibacterial agent 98
	Antibacterial agent 98 (compound g37) 是口服有效的抗菌剂，可以抑制 Gyrase B 的 ATP 酶活性并削弱金黄色葡萄球菌 (S. aureus )的DNA 超螺旋。Antibacterial agent 98 不会诱导 MRSA (耐甲氧西林金黄色葡萄球菌 (S. aureus)) 的耐药性发展。
T70386	QZN34
	QZN34 is a PqsR inhibitor which prevents S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development. The mechanism of action of QZN 34 toward Gram-positive bacteria is shown to involve membrane perturbation and dissipation of transmembrane potential.
T70798	Benastatin B
	Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S....
T80047	Polistes mastoparan
	Polistes mastoparan 作为一种抗菌肽，能够增强S. aureus (金黄色葡萄球菌) 的K+流失并削弱其活性，其EC50为5 μM。
T80370	Maximin 42
	Maximin 42为一抗菌肽，针对S. aureus表现出抗菌活性（MIC: 37.5 μg/mL），同时对人红细胞具溶血活性。
T80290	PP102
	PP102为一种抗菌肽，针对革兰氏阴性及革兰氏阳性细菌展现出抗菌效能，具体作用于B. subtilis（MIC: 25 uM）、S. aureus（MIC: 13 uM）、S. lutea（MIC: 63 uM）和B. pumilu（MIC: 23 uM）。
T80414	ASP-1
	ASP-1是一种活性强的抗葡萄球菌肽，其对金黄色葡萄球菌及耐甲氧西林金黄色葡萄球菌(MRSA)的最低抑制浓度(mic)范围为2μg/mL至64μg/mL。
T36032	Desotamide
	Desotamide is a cyclic hexapeptide antibiotic originally isolated from Streptomyces. It is active against S. aureus, S. pneumoniae, and methicillin-resistant S. epidermidis (MRSE; MICs = 16, 12.5, and 32 μg/ml, respectively).
T38290	Leucomycin A4 Leucomycin A4
	Leucomycin A4 is a macrolide antibiotic that has been found in S. kitasatoensis. It is active against a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 μg/ml, respectively).
T77111	Omodenbamab
	Omodenbamab 是一种抗 SpA(葡萄球菌蛋白 A) 人源化单克隆抗体，KD 值为 0.0467 nM。Omodenbamab 通过靶向细胞壁部分蛋白 A (SpA) 来规避关键的 S. aureus 逃避机制。Omodenbamab 可用于 S. aureus 血流感染的研究。

化合物

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Cat.No: T8507

Target: Antibacterial

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Cat.No: T19794

Synonym: 替马沙星,Omniflox

Target: Antibiotic

Cloxacillin sodium monohydrate

Cat.No: T1031

Synonym: Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物

Target: Antibacterial, Antibiotic

Garenoxacin mesylate hydrate

Cat.No: T7804

Synonym: Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate)

Target: Antibacterial

Dyclonine hydrochloride

Cat.No: T1389

Synonym: 盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl

Target: Sodium Channel, Antibacterial, Antifungal

Cat.No: T1283

Synonym: 克林沙星,PD 127391,CI-960,AM-1091

Target: Antibacterial, Antibiotic

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

Cat.No: T7179

Synonym: BMS284756,加雷沙星

Target: Antibacterial

Cat.No: T1293

Synonym: BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155,加替沙星

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T64316

Synonym: 1-((4-Nitrophenyl)sulfonyl)piperidine

Cat.No: T12126

Synonym: Fab-001

Target: Antibacterial

Cat.No: TQ0063

Synonym: ETX0914,AZD0914

Target: DNA gyrase, DNA/RNA Synthesis, Topoisomerase, Antibacterial

Cat.No: T22387

Synonym: 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione

Target: Others

Lauramine oxide

Cat.No: T20936

Synonym: LDAO,Dimethylaurylamine oxide,十二烷基二甲基氧化胺,Refan,Lauryldimethylamine oxide

Target: Antibacterial

Cat.No: T4208

Target: Antibacterial

CysHHC10 acetate

Cat.No: TP1663L

Synonym: CysHHC10 acetate(1408311-03-4 free base)

Target: Antibacterial

Antibacterial agent 26

Cat.No: T61159

Target: Antibacterial

Cat.No: TQ0113

Synonym: 艾拉普林,AR-100

Target: Antibacterial, Antibiotic

Cat.No: T6638

Synonym: 瑞他莫林,SB-275833

Target: ribosome, Antibacterial, Antibiotic

Olanexidine hydrochloride

Cat.No: T28229

Synonym: OPB2045,OPB-2045,OPB-2045 HCl,OPB 2045

Target: Antibacterial

Cat.No: T10586L

Synonym: NSC50460

Target: Others, Antibacterial

Cyclo(L-Phe-L-Pro)

Cat.No: TN6672

Target: Free radical scavengers, COX, Antibacterial, Antifungal

RNAIII-inhibiting peptide TFA

Cat.No: TP1412

Synonym: RNAIII-inhibiting peptide(TFA),L-酪氨酰-L-丝氨酰-L-脯氨酰-L-色氨酰-L-苏氨酰-L-天冬氨酰胺酰-L-苯丙氨酸

Target: Antibacterial

Cat.No: T19642

Synonym: CG 0549,CG-0549,CG-400549,CG 400549,CG0549,CG400549

Target: Antibacterial

Cat.No: TP1773L

Target: Antibacterial, Antibiotic

Cat.No: T21358

Synonym: BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星

Target: Antibacterial, Antibiotic

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Antibacterial agent 19

Cat.No: T72330

SYNV-cyclo(CGGYF)

Cat.No: T76658

4-Chloroguaiacol

Cat.No: T36594

Cat.No: T10587

Target: Others

Cat.No: T80293

Cat.No: T27389

SYNV-cyclo(CGGYF) TFA

Cat.No: T76658L

Antibacterial agent 87

Cat.No: T64069

Cat.No: T38334

Cat.No: T80373

Cat.No: T38102

Antibacterial agent 98

Cat.No: T61911

Cat.No: T70386

Cat.No: T70798

Polistes mastoparan

Cat.No: T80047

Cat.No: T80370

Cat.No: T80290

Cat.No: T80414

Cat.No: T36032

Cat.No: T38290

Synonym: Leucomycin A4

Cat.No: T77111

Cat. No.	Product Name	Target	Signaling Pathways
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
T3381	Lysionotin 岩豆素	Others	Others
	Lysionotin (Nevadensin) 是一种类黄酮，分离自黄花草药中。它可抑制 α-Toxin (一种成孔蛋白) 的表达，并在体内和体外针对金黄色葡萄球菌显示出显著的保护作用。它可用于研究由金黄色葡萄球菌引起的肺炎。
T5802	Stearyl glycyrrhetinate	Antiviral; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Stearyl glycyrrhetinate 是甘草提取物中的主要成分之一，具有抗菌作用，对金黄色葡萄球菌菌株的 MIC 大于 256 mg/L。
TN2730	2,5-Dihydroxybenzaldehyde Gentisaldehyde,2,5-二羟基苯甲醛	Anti-infection; Antibacterial	Microbiology/Virology
	2,5-Dihydroxybenzaldehyde (Gentisaldehyde) 是一种天然抗微生物剂，可抑制Mycobacterium avium subsp. paratuberculosis 的生长。它还抑制金黄色葡萄球菌菌株，MIC50为 500 mg/L。
T1126	Penicillin V Potassium 青霉素V钾,Penicillin V potassium salt,Phenoxymethylpenicillin potassium salt	Antibacterial; Antibiotic	Microbiology/Virology
	Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) 是一种有口服活性的抗生素。它可抑制链球菌，艰难梭菌和金黄色葡萄球菌的生长，可研究中耳炎，鼻窦炎，咽炎和扁桃体炎。
T8384	Gatifloxacin hydrochloride AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Gatifloxacin hydrochloride (AM-1155 hydrochloride) 是一种氟喹诺酮类抗生素，有广谱抗菌活性。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml) 。它在动物模型中，可研究细菌性结膜炎。
T13708	Glycol chitosan 羟乙基脱乙酰壳多糖,乙二醇壳聚糖	Antibacterial	Microbiology/Virology
	Glycol chitosan 是具有亲水性乙二醇支链的壳聚糖衍生物。它抑制大肠杆菌，金黄色葡萄球菌和肠炎链球菌的生长，MIC 值分别为 4 μg/mL，32 μg/m L 和 <0.5 μg/mL。它可增强 Glycine max Harosoy 63W 细胞的膜通透性和渗漏。
TN1524	Continentalic acid	NOS; COX; Antibacterial; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Continentalic acid 是来自 Aralia continentalis 的，对金黄色葡萄球菌的 MIC 约为 8-16 µg/mL，包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。
TN7094	Coreoside B	Antibacterial	Microbiology/Virology
	Coreoside B 是从coreoside 中分离出来的，对金黄色葡萄球菌和炭疽杆菌显示出较弱的抗菌活性。
T37267	Pachybasin	Antibacterial	Microbiology/Virology
	Pachybasin 是一种蒽醌真菌代谢物。 Pachybasin 对大肠杆菌、枯草芽孢杆菌、M. luteus、S. cerevisiae、C. albicans、A. niger 和 A. flavus 具有抗菌活性，MIC 值为 64.0 μg/mL，对金黄色葡萄球菌具有抗菌活性和尖孢镰刀菌，MIC 值分别为 32.0 和 16.0 μg/mL。
TN2281	Sinapaldehyde trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛	Antibacterial	Microbiology/Virology
	Sinapaldehyde (trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde) 对耐甲氧西林的金黄色葡萄球菌和大肠杆菌有抗菌作用，MIC 值都为 128 μg/mL。
TN2898	Kaempferol-7,4'-dimethyl ether 3,5-Dihydroxy-4',7-dimethoxyflavone	Antioxidant; Antifection	Microbiology/Virology; oxidation-reduction
	Kaempferol-7,4'-dimethyl ether 是从 Zingiber phillipseae 的根茎中分离得到的，对金黄色葡萄球菌和大肠杆菌具有抗氧化活性，MIC 分别为 200 和 225 μg/ml。
TN1949	Moracin C 桑辛素 C,5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇	ROS; NO Synthase	Immunology/Inflammation
	Moracin C 是一种发现于Morus mesozygia、Morus alba var. multicaulis 中的天然化合物，是一种抗炎剂。Moracin C 可抑制细胞中的一氧化氮（NO）释放和LPS 激活的活性氧（ROS）。
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
T13305	Viridicatol	Anti-infection; Antifungal	Microbiology/Virology
	Viridicatol 是从夹竹桃的内生真菌青霉菌属的发酵中分离出的一种喹诺酮类生物碱，对金黄色葡萄球菌有抗菌活性，MIC 值为 15.6 μg/mL。
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
TN2447	Isovalerylshikonin	Antibacterial	Microbiology/Virology
	Isovalerylshikonin 是太子参和紫草的天然产物。
TN1722	Hamamelitannin	Antifection	Microbiology/Virology
	Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚，是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
T6873	Lauric Acid 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	Lauric Acid (Dodecylic acid) 是一种有抗菌活性的中链脂肪酸，对P. acnes，S.aureus 和S. epidermidis 的 EC50值分别为 2，6，4 μg/mL。
TC0017	Haplopine	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells.
T72805	(±)-Hydnocarpin
	(±)-Hydnocarpin 是一种黄酮木脂素。(±)-Hydnocarpin 可以抑制S. aureus 的生长，MIC50值为 3.1 μM。
TN3216	(3R)-7,4’-Dihydrohomoisoflavanone 7,4'-Dihydroxyhomoisoflavanone	Antibacterial	Microbiology/Virology
	(3R)-7,4’-Dihydrohomoisoflavanone 是一种天然化合物，对金黄色葡萄球菌和耐甲氧西林金黄色葡萄菌（MRSA）都具有强大的抗菌性能。
TN4725	Oxychelerythrine	Antifection	Microbiology/Virology
	Oxychelerythrine shows high modulatory activity enhancing the susceptibility of the S. aureus ATCC 6538 to all the tested antibiotics from two to four-fold. It also shows antifeeding activities against Tribolium castaneum adults, with the EC50 of 192.32 p
T27024	Citromycetin Frequentic Acid,NSC-53584,NSC 53584,NSC53584
	Citromycetin is a fungal metabolite originally isolated from Australian P. frequentans. It has antibiotic activity against the Gram-negative bacteria V. cholerae and S. flexneri and the Gram-positive bacteria S. aureus.
T35754	Aszonapyrone A
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34...
T36417	Nargenicin Antibiotic 47444
	Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (...
TN3573	Camaric acid	Antifection	Microbiology/Virology
	Camaric acid shows antibacterial activity against Staphylococcus aureus and methicillin resistant S. aureus with IC50 values 8.74 and 8.09 uM, respectively, it also shows moderate antileishmanial activity and highly potent antitrypanosomal activity. Camar
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
TN2809	22-Dehydroclerosterol	Antifection	Microbiology/Virology
	22-Dehydroclerosterol has antibacterial activity against against E. coli, S. aureus, and H. pylori.
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
T69058	OM173-αA
	OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton.
TN1526	Corydalmine	P450; Antifection	Metabolism; Microbiology/Virology
	Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spore germination of all the fungi at 100 to 1500 ppm. l-Corydalmine also exhibits potent analgesic activity in preclinical models, it is under development as an oral analgesic agent.
TN5404	(+)-Conocarpan
	Conocarpan has antinociceptive effects. Conocarpan is quite active against S. aureus and B. subtilis with MIC of 6.25 micrograms/ml, it also shows activity against M. tuberculosis (MIC=15.6 ug/ml). Conocarpan shows considerable activity against epimastigo
TN5466	Boeravinone B
	Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exh
T36044	17-hydroxy Venturicidin A
	17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.
TN4319	Isopimaric acid	Antifection	Microbiology/Virology
	Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
TN3404	Altholactone	BCL; p38 MAPK; ROS; Akt; Caspase; Antifection; p53	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis via oxidative stress, including bladd
T83862	Bactobolin A hydrochloride BN-183B
	Bactobolin A 是一种最初从 Pseudomonas 中分离出的微生物代谢产物，具有抗生素和抗癌活性。它对 S. aureus、S. epidermidis、S. faecalis、B. anthracis、B. subtilis、E. coli、S. typhi 和 S. dysenteriae 活跃(MICs = 0.1-12.5 µg/ml)。在体内，bactobolin A (0.25-4 mg/kg) 提高了 L1210 小鼠白血病模型的存活率。
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T37442	Aspergillin PZ
	Aspergillin PZ is a fungal metabolite originally isolated from A. awamori. It induces morphological deformation of P. oryzae conidia when used at a concentration of 89 nM. Aspergillin PZ is active against S. epidermidis (MIC = 20 μM) but not S. aureus, E. coli, or B. cereus (MICs = >20 μM). It is cytotoxic to HL-60 promyelocytic leukemia cells (IC50 = 56.61 μM) but not THP-1 acute monocytic leukemia or PC3 prostate cancer cells (IC50s = >80 μM).
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
T83918	Clazamycin A hydrochloride NSC 332188
	Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性，包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa（MICs分别为100、6.25、100、50和25 µg/ml）。
T38086	Neohydroxyaspergillic Acid
	Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ...
T73207	Laburnetin
	Laburnetin 是一种异黄酮类抗菌剂 (antibacterial agent)。Laburnetin 对真菌、S. vesicarium 具有抗菌活性。Laburnetin 增强了耐甲氧西林 (Methicillin) 金黄色葡萄球菌 (MRSA) 菌株对甲氧西林的敏感性。Laburnetin 可用于控制栽培物种的虫害。
T80330	XT-1
	XT-1是一种抗菌肽，源自热带爪蟾Xenopus tropicalis的皮肤分泌物，表现出对S.aureus、E.coli和C.albicans的强烈活性，其最小抑菌浓度(MIC)分别为5μM、6μM和50μM。
T75439	Angustifoline hydrochloride
	Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱，展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用，证明了其抗菌活性。
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
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天然产物

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: T3381

Synonym: 岩豆素

Target: Others

Stearyl glycyrrhetinate

Cat.No: T5802

Target: Antiviral, Antibacterial

2,5-Dihydroxybenzaldehyde

Cat.No: TN2730

Synonym: Gentisaldehyde,2,5-二羟基苯甲醛

Target: Anti-infection, Antibacterial

Penicillin V Potassium

Cat.No: T1126

Synonym: 青霉素V钾,Penicillin V potassium salt,Phenoxymethylpenicillin potassium salt

Target: Antibacterial, Antibiotic

Gatifloxacin hydrochloride

Cat.No: T8384

Synonym: AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride),加替沙星盐酸盐

Target: Topoisomerase, Antibacterial, Antibiotic

Glycol chitosan

Cat.No: T13708

Synonym: 羟乙基脱乙酰壳多糖,乙二醇壳聚糖

Target: Antibacterial

Continentalic acid

Cat.No: TN1524

Target: NOS, COX, Antibacterial, Prostaglandin Receptor

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

Cat.No: TN7094

Target: Antibacterial

Cat.No: T37267

Target: Antibacterial

Cat.No: TN2281

Synonym: trans-3,5-Dimethoxy-4-hydroxy cinnamaldehyde,TRANS-3,5-二甲氧基-4-羟基肉桂醛,芥子醛

Target: Antibacterial

Kaempferol-7,4'-dimethyl ether

Cat.No: TN2898

Synonym: 3,5-Dihydroxy-4',7-dimethoxyflavone

Target: Antioxidant, Antifection

Cat.No: TN1949

Synonym: 桑辛素 C,5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇

Target: ROS, NO Synthase

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Cat.No: T13305

Target: Anti-infection, Antifungal

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Isovalerylshikonin

Cat.No: TN2447

Target: Antibacterial

Cat.No: TN1722

Target: Antifection

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

Cat.No: T6873

Synonym: 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid

Target: Others, Endogenous Metabolite, Antibacterial

Cat.No: TC0017

Target: Tyrosinase, Antifection

(±)-Hydnocarpin

Cat.No: T72805

(3R)-7,4’-Dihydrohomoisoflavanone

Cat.No: TN3216

Synonym: 7,4'-Dihydroxyhomoisoflavanone

Target: Antibacterial

Oxychelerythrine

Cat.No: TN4725

Target: Antifection

Cat.No: T27024

Synonym: Frequentic Acid,NSC-53584,NSC 53584,NSC53584

Cat.No: T35754

Cat.No: T36417

Synonym: Antibiotic 47444

Cat.No: TN3573

Target: Antifection

Cat.No: TN6010

22-Dehydroclerosterol

Cat.No: TN2809

Target: Antifection

Cat.No: TN3978

Target: Antifection

Cat.No: T69058

Cat.No: TN1526

Target: P450, Antifection

Cat.No: TN5404

Cat.No: TN5466

17-hydroxy Venturicidin A

Cat.No: T36044

Isopimaric acid

Cat.No: TN4319

Target: Antifection

Cat.No: TN3404

Target: BCL, p38 MAPK, ROS, Akt, Caspase, Antifection, p53

Bactobolin A hydrochloride

Cat.No: T83862

Synonym: BN-183B

Antibacterial synergist 2

Cat.No: T72235

Cat.No: T37442

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

Antibiotic PF 1052

Cat.No: T38097

Clazamycin A hydrochloride

Cat.No: T83918

Synonym: NSC 332188

Neohydroxyaspergillic Acid

Cat.No: T38086

Cat.No: T73207

Cat.No: T80330

Angustifoline hydrochloride

Cat.No: T75439

Cat.No: T38016

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